Physician Investigator (Cl) Interdisciplinary Brain Center, Mass General Research Institute

Associate Professor of Neurology Harvard Medical School

MD University of Chicago Pritzker School of Medicine 1992

alzheimer's disease; atrophy; brain; cerebral cortex; corpus callosum; creatine; huntington disease; imaging; nerve fibers myelinated; neuroimaging; parahippocampal gyrus; trinucleotide repeats Dr. Rosas and her team have focused primarily on the development of biomarkers for use in the study of neurodegenerative diseases, to better characterize progression, to better understand genotype/phenotype correlations, and to apply novel neuroimaging approaches in clinical trials with the overall aim of making them more efficient. We have begun to develop models that may explain clinically heterogeneous phenotypes and variability in disease progression.

The current models for both disease prediction and prediction of disease progression are insensitive and inaccurate. We are planning to expand our efforts to include multi-modal and multi-spectral imaging approaches that promise both more precise measurements and made provide novel and important information on the neural underpinnings of HD and their clinical consequences.