Physician Investigator (Cl) Pediatric Pulmonary Medicine, Mass General Research Institute

Associate Professor of Pediatrics Harvard Medical School

anoxia; apnea; cell migration and motility; congenital hypoventilation syndrome; glomerulonephritis membranous; gtp-binding protein alpha subunits gi-go; gtp-binding proteins; lung; nerve growth factors

Dr. Kinane's research focuses on 3 distinct areas:

Regulation of cell migration:- Dr. Kinane's group focuses on transduction pathways that regulate cell migration and lung development.  He has identified novel regulators of lung cell and inflammatory migration including Netrins. He found that these Netrin like molecules are critical in regulation of lung development and inflammatory responses. This research has broad implications for congenital lung malformation, blood vessel inflammation including coronary artery disease and autoimmune disease. 

Regulation of the control of breathing:- In patients with central congenital hypoventilation syndrome, his group identified one of the molecular mechanisms of this syndrome. Recently he has extended this work to the regulation of breathing in common physiological conditions.  He has recently focused his studies on airway obstruction in infants while placed in a car seat. This work has resulted in a number of highly cited manuscripts. 

Pediatric interstitial lung disease:- Dr. Kinane's group works on the genetic basis, classification and treatment of interstitial disease. He has developed a genetics clinic in pulmonary to support this work.