Saeed Nazemidashtarjandi, Ph.D.

Dr. Saeed Nazemidashtarjandi leads a translational bioengineering research program focused on resolving inflammation through monocyte and macrophage reprogramming. His work integrates immunometabolism, mitochondrial biology, and bioengineered delivery systems to develop targeted therapeutic strategies for inflammatory bowel disease (IBD) and related chronic inflammatory conditions. By restoring immune balance and promoting tissue repair, his research addresses the need for safer, more durable alternatives to broad immunosuppressive therapies.

He also studies monocyte subset remodeling and immune dysregulation in patients with major burn injuries, with the goal of identifying therapeutic targets that can improve inflammatory resolution, recovery, and survival after severe injury.

In addition, Dr. Nazemidashtarjandi investigates the nano–bio interface, focusing on how engineered nanomaterials interact with cell plasma membranes. His work examines how lipid chemistry, membrane organization, and the protein corona regulate nanomaterial uptake, biodistribution, toxicity, and therapeutic performance. These studies support the rational design of safer and more effective nanomaterials for biomedical use.