Yi Xin, PhD

Instructor in Investigation
Anesthesia, Critical Care and Pain Medicine, Mass General Research Institute
PhD University of Pennsylvania 2021
acute lung injury; computed tomography; lung ventilation; magnetic resonance imaging; perfusion imaging

My research focuses on the development of functional imaging techniques to visualize the progression of lung injury—with a particular emphasis on acute respiratory distress syndrome (ARDS). My graduate studies primarily focused on developing image processing techniques (computed tomography and hyperpolarized magnetic resonance) to assess regional responses to ARDS treatments (e.g., prone positioning, ventilator management, inhaled nitric oxide, endothelial barrier protectors). I developed a registration approach to align images obtained at different levels of inflation, yielding detailed maps of regional lung ventilation. This work allowed us to identify regions of the lung at higher risk of worsening lung injury due to harmful tidal strain during mechanical ventilation. I am currently working on novel models that will enable the mapping of lung perfusion on dual energy and dynamic computed tomography to phenotype ARDS and guide treatment strategies through the assessment of integrated maps of pulmonary perfusion and inflation mechanics.