Yiying Zhang, M.D., Ph.D


Assistant Professor of Anaesthesia
Harvard Medical School
Assistant Investigator
Anesthesia, Critical Care and Pain Medicine, Mass General Research Institute
MS Xuzhou Medical College 2009
MD Xuzhou Medical College 2006
Ph.D Shanghai Tongji University 2018
anesthesia; cognitive disorders; delirium dementia; microbiome-gut-brain axis; mitochondria

Research Areas

  • Understanding the mechanism of anesthetics and surgery effect on mitochondrial function. 

  • Gut microbiome-neuroinflammation-mitochondria relation on Brain

  • Aging and anti-aging by gut microbiome.

Description of Research

Dr. Zhang's research focuses on Alzheimer’s disease (AD) neuropathogenesis, anesthesia neurotoxicity, anesthesia/surgery toxicity, postoperative neurocognitive disorder and postoperative delirium (POD) since 2009. Dr. Zhang specifically studied the effects of anesthetics on mitochondrial function in vitro and in vivo, as well as the potential association between neuroinflammation and mitochondrial function following the anesthesia and/or surgery. 
Dr. Zhang have focused on studying potential gut microbiome-neuroinflammation-mitochondria cascade in the pathogenesis of POD and demonstrated that there are age-dependent specific gut microbiome profile (microbiome dysbiosis), age-dependent mitochondrial dysfunction, and age-dependent POD-like behavior in the mice. Moreover, Dr. Zhang have found that the anesthesia/surgery is able to decrease gut lactobacillus in the aged mice and the oral treatment of lactobacillus is able to mitigate the POD-like behavior in the aged mice.

Research lab website Publications Clinical Profile
yzhang37@mgh.harvard.edu
(617) 643-2468
Anesthesia, Critical Care and Pain Medicine
CNY-Building #149
149 13th Street
3414
Charlestown, MA 02129