Physician Investigator (Cl) Allergy and Clinical Immunology Unit, Mass General Research Institute

Assistant Professor of Medicine Harvard Medical School

Temporary Academic Medicine, Harvard Medical School

Associate Physician Allergy and Clinical Immunology Unit, Massachusetts General Hospital

MD Duke University School of Medicine 2006

basophils; carboplatin; desensitization, immunologic; drug hypersensitivity; hypersensitivity, immediate

Antibodies play a central role in allergic diseases.  The Patil Laboratory is focused on the study of allergen-specific antibodies in allergic diseases.  We are focused on understanding and harnessing protective antibodies induced by immunotherapy for food allergies.  In the course of our investigation, we have developed new techniques to study antigen-specific B cells, including the use of fluorescent multimers.  Combined with single cell B cell receptor sequencing and deep sequencing of the antibody repertoire, we have been able to better understand the development of clinical tolerance in immunotherapy.

We believe that by understanding the development and functionality of antigen-specific B cells, the B cell repertoire, and protective antibodies, we will be able to contribute to the next generation of therapies.