Investigator, Instructor HVI CV MGH Das Research PO, Mass General Research Institute

Instructor in Medicine Harvard Medical School

Bachelor of Sciences (Honours) Sri Sathya Sai Institute of Higher Learning 2010

Master of Sciences (Biotechnology) Sri Sathya Sai Institute of Higher Learning 2012

Doctor of Philosophy in Biomolecular Sciences Marie-Curie Fellowship - Institute of Endocrinology and Oncology, CNR and University of Campania at Luigi Vanvitelli, Italy 2019

biomarkers; biomarkers for heart failure; cardiomyocytes; cardiovascular diseases; extracellular vesicles; long non-coding rnas; next-gen sequencing; novel diagnostics and therapeutics; pericytes; rna; rna antisense

My research focuses on non-coding RNAs as tools for understanding and treating cardiovascular disease. During my PhD at the CNR in Naples, I studied long non-coding RNAs (lncRNAs) in ovarian cancer, before moving into the cardiovascular field for my postdoctoral training at the Cardiovascular Research Center, MGH/HMS. There, supported by an American Heart Association Postdoctoral Fellowship, I used patient-derived samples to identify RNA and protein biomarkers in heart failure, and developed tissue-specific EV-based liquid biopsy approaches to non-invasively monitor myocardial disease in plasma — optimizing and leveraging EV long-RNA profiling using next-generation sequencing and precise quantitative estimation using qRT-PCR and dPCR. In parallel, I worked on modified siRNA therapeutics validated in preclinical models of CVD including heart-on-chip and mouse models, bridging RNA biology with therapeutic development.

My research program focuses on two connected goals: expanding tissue-specific EV-based liquid biopsy across accessible biofluids such as plasma and saliva for cardiac disease monitoring, and developing RNA therapeutics to treat adverse cardiac remodeling. Both directions are driven by patient-sample-based discovery and tested in mouse and heart-on-chip models.