David Hooper, M.D.

Physician Investigator (Cl)
Infectious Disease, Mass General Research Institute
Professor of Medicine
Harvard Medical School
Infectious Disease, Massachusetts General Hospital
MD Washington University School of Medicine in St. Louis 1973
anti-infective agents; antibiotic resistance; bacterial proteins; drug resistance bacterial; e coli; enterococcus; fluoroquinolones; nora; quinolone resistance; quinolones; staphylococcus aureus My laboratory studies the mechanisms and epidemiology of antibiotic resistance in bacteria with a major focus on the molecular determinants of quinolone action and resistance in Staphylococcus aureus and Escherichia coli. The work includes characterization of the regulation of expression, membrane topology, and structure-activity relationships of the NorA and related quinolone efflux transport proteins of S. aureus; genetic dissection of the roles of topoisomerase IV and DNA gyrase in DNA replication, in regulation of virulence gene expression, and as drug targets; epidemiologic analyses of quinolone resistance and factors determining rates of antibiotic resistance in hospitals; molecular determinants favoring clonal spread of vancomycin-resistant Enterococcus faecium; and role of perioperative antibiotic use in selection of resistant bacteria.
Publications Clinical Profile

Gray / Jackson
80 Blossom Street
Boston, MA 02114