Jill Goldstein, Ph.D., M.P.H.
Founder and Executive Director Innovation Center on Sex Differences in Medicine (ICON-X), Massachusetts General Hospital |
Investigator, Full Professor (M) Psychiatry, Mass General Research Institute |
Helen T. Moerschner Endowed MGH Research Institute Chair in Women's Health Massachusetts General Hospital |
Professor of Psychiatry Harvard Medical School |
Professor of Medicine Harvard Medical School |
Education
M.P.H. Columbia University, School of Public Health 1979 |
Honorary M.A. Harvard University 2004 |
Research Interests
Research Narrative
Dr. Goldstein is a clinical neuroscientist, Professor of Psychiatry and Medicine at HMS, Founder and Executive Director, Innovation Center on Sex Differences in Medicine at MGH and the Helen T. Moerschner Endowed MGH Research Institute Chair in Women's Health.
For >30 years, her lab has been investigating sex differences in the human brain across the lifespan and their implications for understanding sex differences in psychiatric disorders (particularly, major depression) and comorbidities with cardiovascular disease and Alzheimer’s disease.
She is an expert in structural and functional brain imaging and detailed clinical and cognitive phenotyping that are associated with steroid hormones, autonomic, immune, and vascular function, and genetics. She has a long history of expertise in longitudinal modeling across the lifespan of complex behavioral traits and disorders combining multiple phenotypic domains.
Her program of research, called the Clinical Neuroscience Laboratory of Sex Differences in the Brain, consists of an interdisciplinary team of investigators, integrating structural and functional brain imaging studies, psychophysiology, neuroendocrine studies, genetics/genomics/transcriptomics, immune function, and collaborative efforts with model animal studies of genes, hormones, immunity and the brain.
The lab has contributed to identifying fetal stress-immune biomarkers that disrupt the healthy sexual differentiation of the brain that are retained and expressed in adulthood as sex differences in deficits in stress and memory circuitries, major depression and comorbid physiologic and vascular abnormalities.
She has a long history training the next generation about sex differences in medicine and women’s health, particularly the impact of hormones and genes and methodologies necessary to test for sex effects.
She has dedicated her career for >30 years at Harvard to teaching and supervising trainees at all levels regarding the science of sex differences in medicine as well as mentoring and sponsoring their career trajectories.
In the service of this, she has been the PI of the K12 Office for Research on Women’s Health training program at Harvard called Building Interdisciplinary Careers in Women’s Health (BIRCWH) for ~20 years.
In 2018, she launched at MGH the Innovation Center on Sex Differences in Medicine (called ICON-X), a collaborative effort between MGH and sister institutions that crosses disciplines, methodologies, and departments whose tagline is “when it comes to health, sex matters”. The mission is to enhance discoveries of sex differences and, more importantly, translate them into developing what they call sex-selective diagnostic tools and therapies to contribute critically to precision medicine.
jill_goldstein@hms.harvard.edu ; and jmgoldstein@mgh.harvard.edu |
(617) 724-3776 |
Psychiatry Lab is at 149 13th Street; Goldstein office and ICON-X is at 185 Cambridge St. CNY - 4th floor; Simches 2nd floor Charlestown (CNY) and Boston (Simches), MA 02114-2000 |