John Stone, M.D.
Physician Investigator (Cl)
Rheumatology Unit, Mass General Research Institute
Professor of Medicine
Harvard Medical School
Rheumatology Unit, Massachusetts General Hospital
|MD Harvard Medical School 1990|
I am currently the Co-PI of a second multi-center clinical trial in ANCA-associated vasculitis: Rituximab in ANCA-Associated Vasculitis (RAVe). This trial, which includes 8 centers in both the United States and Europe, is sponsored by the Immune Tolerance Network (NIAID). The primary results of this trial were recently published in The New England Journal of Medicine (2010).
My most current research interest pertains to an emerging disease known as IgG4-related systemic disease (IgG4-RSD). My research group at the MGH made the seminal observation that rituximab therapy leads to the targeted reduction of the IgG4 subclass of immunoglobulins in this disorder, with maintenance of normal levels of other IgG subclasses.