David Pyle, MD, PhD


Physician Investigator (Cl)
Pediatric Allergy Group, Mass General Research Institute
Assistant In Pediatrics
Pediatric Allergy Group, Massachusetts General Hospital
M.D.; Ph.D. UT Southwestern Medical School 2015
food allergies; oral immunotherapy; peanut hypersensitivity; pediatric food allergies

I am an allergy/immunology physician who specializes in the care of pediatric food allergy. I was born and raised in Texas and attended UT Southwestern Medical School obtaining an MD degree as well as a PhD in Immunology. After completing my residency training in Pediatrics at Yale-New Haven Hospital, I joined the Allergy and Immunology department at Massachusetts General Hospital (MGH) and Harvard Medical School (HMS) as a Clinical and Research Fellow. I completed my fellowship training in June 2020 and transitioned to a faculty position as Assistant Instructor in Pediatrics at MGH and HMS. In my current role, I provide clinical care in the Pediatric Allergy and Immunology Clinic and conduct research on oral immunotherapy for food allergy to enhance our knowledge and the quality of patient care.

My clinical interests and expertise revolve around the care of pediatric food allergies. During my fellowship at MGH, I was actively involved in clinical work, providing treatment for adult and pediatric patients with a variety of allergic or immunologic conditions. I have identified pediatric food allergy as my area of focus and have worked to gain clinical experience in this area. I am involved in several clinical trials around food allergy oral immunotherapy as well as participating in the clinical Peanut Oral Immunotherapy program with the MGH Food Allergy Center. I also participate in research within the MGH Center for Immunologic and Inflammatory Diseases as part of the Shreffler Lab. My research focuses on the use of bioinformatics and data science to gain insight into the mechanisms and outcomes of oral immunotherapy for food allergy.