Bakhos Tannous, Ph.D.

Professor of Neurology
Harvard Medical School
Neurology, Mass General Research Institute
PhD University of Windsor 2002
blood platelets; cancer diagnosis; cancer stem cells; diffuse intrinsic pontine glioma; experimental therapies for glioblastomas; extracellular vesicles; genes reporter; glioblastoma; glioma; high-throughput screening assays; luciferases; pediatric brain tumors

The Tannous lab focuses on developing novel imaging, diagnostics and therapeutic strategies for adult and pediatric brain tumors, with a primary focus on cancer stem cells. Their work includes:

(1) Characterization of the naturally secreted Gaussia luciferase (Gluc) as a blood reporter for monitoring different biological processes including tumor response to therapy, viral infection, circulating stem/neuroprogenitor/T-cells.

(2) Engineering different secreted reporters for multiplex high-throughput screening assay to find novel therapeutics against different cancer stem cells state.

(3) Drug Repurposing for glioma therapy some of which are currently being tested in clinical trials.

(4) Developing the concept of metabolic biotinylation of tumor receptors to target imaging and therapeutic agents to brain tumor

(5) Understanding the role of extracellular vesicles in gliomagenesis and therapeutic resistance.

(6) Tumor-educated platelets (TEP) for pan-cancer, multi-class detection as well as biomarker discovery and their potential for longitudinal disease monitoring and response to therapy and their role tumor development and therapeutic resistance.

(7) Developing novel gene and cell therapies against gliomas as well as novel delivery vehicle to target cancers of the brain.