Assistant Professor of Radiology Harvard Medical School

calcium channels; fluorination; pet; pet imaging; pet tracer development; pet tracers; potassium channels; radiofluorination; radioligands; small molecule pet radioligands

The focus of our group is to develop new small molecule PET radioligands for brain disorders and immunoPET. We are particularly interested in developing tracers for potassium channels in the brain to image multiple sclerosis (see Developing a PET tracer for K⁺ channels) and tracers for calcium channels to image epilepsy and pain (see Developing PET tracers for Ca²⁺ channels).

We are also interested in developing small molecules to image therapeutic monoclonal antibodies using a pretargeting approach (see PET-tag: a new approach to imaging monoclonal antibodies) and exploring new radiochemistry to make our tracers (see New fluorination and radiofluorination strategies).