Mariel Kozberg, M.D., Ph.D.
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Clinicn Investigator, Instruct Neurology, Mass General Research Institute |
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Assistant Professor of Neurology Harvard Medical School |
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Assistant Neurologist Neurology, Massachusetts General Hospital |
| PhD Columbia University, College of Physicians and Surgeons 2016 |
| MD Columbia University, College of Physicians and Surgeons 2016 |
Research Narrative
The Kozberg Lab is dedicated to understanding the mechanisms of blood vessel rupture in the brain and finding ways to prevent brain bleeding.
Our research focuses on cerebral amyloid angiopathy (CAA), a common small vessel disease which is a leading cause of intracerebral hemorrhage. There are no current disease-modifying therapies available for patients with CAA. Our team is deeply motivated by the experiences of patients with CAA; our overarching goal is to develop novel therapeutic strategies that will be effective at the time patients first present with symptoms.
Current projects in the lab center on the contributions of blood-brain barrier leakage, prior brain bleeding, and brain inflammation to blood vessel dysfunction in CAA. We use a range of techniques including in-vivo two-photon microscopy, in-vivo widefield optical imaging, and ex-vivo MRI-guided histopathology, all of which enable us to study changes in brain blood vessels at an individual vessel level.