David J. Gregory, Ph.D.

Instructor in Investigation
Pediatrics, Mass General Research Institute
Instructor in Pediatrics
Harvard Medical School
Research Staff
Pediatrics, Massachusetts General Hospital
Postdoctoral training McGill University, Montréal 2006
PhD University of Dundee 2002
autophagy; covid-19; emerging infectious disease; francisella tularensis; gene expression; inflammasomes; inflammation; innate immune signaling; innate immunity; intracellular pathogens; leishmaniasis; macrophages; molecular biology; tularemia I am a molecular biologist specializing in innate immune signalling and gene expression in response to pathogens. I have worked extensively with neglected and emerging infectious diseses, including Leishmania (a tropical parasite that infects macrophages), Francisella tularensis (Gram negative bacterium that invades macrophages and other cell types and a poteinial biological weapon), and now the host repsonses to SARS-CoV-2 infection (COVID-19). At each stage, this work has involved establishing leading edge whole-genome screening and profiling technologies to interrogate host responses and identify novel therapeutic targets.

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