David J. Gregory, Ph.D.

Instructor in Investigation
Pediatrics, Mass General Research Institute
Research Staff
Pediatrics, Massachusetts General Hospital
Postdoctoral training McGill University, Montréal 2006
PhD University of Dundee 2002
autophagy; covid-19; emerging infectious disease; francisella tularensis; gene expression; inflammasomes; inflammation; innate immune signaling; innate immunity; intracellular pathogens; leishmaniasis; macrophages; molecular biology; tularemia I am a molecular biologist specializing in innate immune signalling and gene expression in response to pathogens. I have worked extensively with neglected and emerging infectious diseses, including Leishmania (a tropical parasite that infects macrophages), Francisella tularensis (Gram negative bacterium that invades macrophages and other cell types and a poteinial biological weapon), and now the host repsonses to SARS-CoV-2 infection (COVID-19). At each stage, this work has involved establishing leading edge whole-genome screening and profiling technologies to interrogate host responses and identify novel therapeutic targets.

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