Investigator, Asst Prof (M) Clinical and Translational Epidemiology Unit, Mass General Research Institute

NON EMPLOYEE RESEARCH Cardiovascular Research Center, Massachusetts General Hospital

PhD Johns Hopkins Bloomberg School of Public Health

MB Hong Kong Baptist University

MS Harvard T.H. Chan School of Public Health

aging; cardiovascular diseases; multi-omics; somatic mutations; statistical genetics My research predominantly involves computational modeling of human multi-omics (somatic and germline DNA mutations, single-cell and bulk RNA, and plasma proteins) data to examine the causes and mechanisms underlying cardiovascular and other age-related diseases. I have developed particular interests and expertise in clonal hematopoiesis (somatic mutation in the blood-forming system) and its interactions with germline omics and drugs. I am also exploring the development of human omics-based instruments utilizing statistical and machine-learning approaches. Throughout my research, I actively collaborate with researchers with other expertise, expanding the breadth and depth of my work. My goal is to contribute to an improved understanding of the mechanisms of age-related diseases and the development of potential therapeutic interventions using large-scale multi-omics data.