Investigator Mongan Institute, Mass General Research Institute

Non Managing EW Cardiology CVRC 1, Massachusetts General Hospital

Member of the Faculty of Medicine Harvard Medical School

PhD Johns Hopkins Bloomberg School of Public Health

MB Hong Kong Baptist University

MS Harvard T.H. Chan School of Public Health

aging; cardiovascular diseases; multi-omics; somatic mutations; statistical genetics My research predominantly involves computational modeling of human multi-omics (somatic and germline DNA mutations, single-cell and bulk RNA, and plasma proteins) data to examine the causes and mechanisms underlying cardiovascular and other age-related diseases. I developed strong expertise in age-related clonal hematopoiesis (clonal expansions in the blood-forming system) and large-scale proteomics. 

Key areas of interest:

• Clonal hematopoiesis and its somatic-germline interplay, with implications for managing associated diseases (in collaboration with Dr. Trevor Fidler).

• Omics-based instruments for testing causal hypotheses in studying diseases.

• Disease risk prediction using static (germline genetic) and dynamic (time-varying factors) data (in collaboration with Dr. Jin Jin).

• Machine learning + proteomics for drug discovery (in collaboration with Dr. Ahmed Alaa).

• Deep learning-derived phenotypes + genetics for understanding diseases (in collaboration with Dr. Vineet Raghu).

I am also an affiliate faculty member at the Broad Institute of MIT and Harvard.