Charles Evavold, PhD

Instructor in Investigation
Ragon PIs 2, Mass General Research Institute
Ragon Institute of MGH, MIT and Harvard
Instructor in Medicine
Harvard Medical School
PhD Harvard University 2021
BS Emory University 2013
cancer biology; cell death; host-pathogen interactions; immunometabolism; inflammasomes; inflammation; innate immunity; vaccine development The Evavold lab studies fundamental cellular decision making towards different cell fates using cell death programs as a model system. We have a particular interest in the intersection of microbiology and metabolism with impact on host cell survival or death.

Regulated cell death can serve different functions within the innate immune system. For example, immunologically silent cell death can remove unnecessary, damaged, or pre-malignant cells during development and homeostasis. Alternatively, during the early containment of a pathogen, inflammatory cell death can alert the immune system to a foreign invader. However, inflammatory cell death can become pathogenic during systemic infection or contribute to sterile autoimmunity and chronic inflammation. Conversely, acquired resistance to cell death programs can promote cancer progression or resistance to chemotherapies. Dysfunction of cell death regulation may underlie much of the pathology related to human diseases. Thus, we aim to uncover novel regulation in these processes using precision screening that combines genomic or chemical perturbations with synthetic biology models of discrete signaling nodes.

Dr. Charlie Evavold received his PhD in Immunology from Harvard University. He received his BS in Physics and Astronomy with a double major in Chemistry from Emory University. Charlie is one of the inaugural Ragon Early Independence Fellows on the basic science track.
Evavold Lab Publications
Ragon Institute of Mass General, MIT, and Harvard
400 Tech Square
400 Technology Square
Cambridge, MA 02139