Investigator, Full Prof (M) Molecular Biology, Mass General Research Institute

Professor of Genetics Harvard Medical School

Professor of Medicine Harvard Medical School

Principal Faculty Harvard Stem Cell Institute

Associate Member Broad Institute

cell dedifferentiation; cloning organism; embryonic stem cells; induced pluripotent stem cells; nuclear reprogramming; nuclear transfer techniques; pluripotent stem cells; soxb1 transcription factors Our lab tries to understand the role that stem cells play in normal development and disease. Stem cells have the dual potential to self-renew and give rise to mature cells. They play key roles in development, during tissue homeostasis and following injury in the adult. Moreover, stem cells have been experimentally shown to be the cells of origin in certain types of cancer. To understand the biology of stem cells and to exploit their use for therapy, it is critical to identify and characterize the factors that control the decision between their self-renewal and differentiation under normal physiological conditions and in disease.