Associate Investigator Center for Cancer Research, Massachusetts General Hospital

Investigator, Assoc Prof (M) KFCCR Faculty, Mass General Research Institute

Professor of Medicine Harvard Medical School

Affiliate Faculty Harvard Stem Cell Institute

carcinoma, pancreatic ductal; cyclin-dependent kinase inhibitor p16; genes, ras; pancreatic neoplasms; protein-serine-threonine kinases; tumor suppressor protein p14arf Pancreatic cancer and biliary cancer are among the most lethal types of human cancers. The Bardeesy laboratory has developed a series of genetically engineered mouse models to define the role of key gene mutations in driving these cancer types. Current projects focus on defining roles for cancer genes in controlling the way cells modulate their growth and utilize energy in response to available nutrients, and on identifying epigenetic regulators responsible for changes in cellular differentiation state that lead to cancer initiation and maintenance.