Lee Josephson, Ph.D.

Associate Professor of Radiology
Harvard Medical School
Honorary Investigator
Gordon Center for Medical Imaging, Mass General Research Institute
Research Staff
Radiology, Massachusetts General Hospital
PhD Stony Brook Medicine 1975
androstadienes; annexin; annexin a5; brain tumor delineation; fluorescent dyes; lymph node delineation; magnetics; mr contrast agents; mri; nanoparticles; nanostructures; nanotechnology; nirf My research focuses on the design and uses of magnetic nanoparticles, near infrared fluorescent (NIRF), and magneto/optical probes for a wide range of questions in biology, chemistry and physics. I have developed nanoparticles that are detectable by MRI and NIRF (magneto/optical probes), and demonstrated their use as pre-operative MR contrast agents and intra-operative optical probes in important clinical applications including lymph node delineation and brain tumor delineation. A second area I am involved with is the development of annexin V based probes for imaging apoptosis, which plays a crucial in the pathology and treatment of disease. Annexin V is used to image the induction of apoptosis by chemotherapy, to predict long-term chemotherapeutic efficacy early in the course of treatment.

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