Physician Investigator (Cl) Cutaneous Biology Research Center, Mass General Research Institute

Associate Professor of Dermatology Harvard Medical School

Assistant In Dermatology Massachusetts General Hospital

Associate Member Broad Institute

Bob and Rita Davis Family MGH Research Scholar 2023-2028 Mass General Research Institute, Massachusetts General Hospital

M.D.; Ph.D. Washington University 2010

alarmins; breast cancer; cancer immunology; cancer immunoprevention; cd4+ t cells; commensal viruses; damps; nk cells; skin cancer The focus of the Demehri laboratory is to determine the role of the immune system in regulating the early stages of cancer development in order to harness its anti-tumor potential for cancer therapy. To date, several cancer immunotherapies have been developed with proven efficacy against late-stage cancers; however, the role of the immune system in preventing the early development of cancer remains uncertain. The research in our laboratory is focused on identifying the immune mechanisms that drive an immune activation sufficient to prevent cancer formation from pre-cancerous lesions. This approach raises a great opportunity to discover novel immune pathways that can be leveraged in cancer therapy and prevention.