Physician Investigator (Cl) Endocrine Division, Mass General Research Institute

Assistant Professor of Medicine Harvard Medical School

Assistant In Medicine Medicine-Endocrinology, Massachusetts General Hospital

Associate Member Broad Institute

M.D.; Ph.D. Harvard Medical School 2009

bone resorption; core binding factor alpha 1 subunit; hyperparathyroidism, secondary; lentivirus; organ size; osteoblasts; osteoclasts; osteogenesis The Wein laboratory studies molecular mechanisms controlling osteocyte differentiation and function. Our research focuses on transcriptional control of sclerostin, an osteocyte-specific secreted protein that happens to be a drug target for osteoporosis. We are interested in understanding how osteocytes turn on sclerostin, and how signals that boost bone formation (parathyroid hormone, mechanical loading) regulate its expression.