Physician Investigator (Cl) Endocrine Division, Mass General Research Institute

Associate Professor of Medicine Harvard Medical School

Assistant In Medicine Medicine-Endocrinology, Massachusetts General Hospital

Associate Member Broad Institute

MGH Research Scholar 2024-2029 Mass General Research Institute, Massachusetts General Hospital

M.D.; Ph.D. 2009

bone resorption; core binding factor alpha 1 subunit; hyperparathyroidism secondary; osteoblasts; osteoclasts; osteogenesis; osteoporosis; osteoporotic fractures The Wein laboratory studies molecular mechanisms controlling osteocyte differentiation and function. Our research focuses on transcriptional control of sclerostin, an osteocyte-specific secreted protein that happens to be a drug target for osteoporosis. We are interested in understanding how osteocytes turn on sclerostin, and how signals that boost bone formation (parathyroid hormone, mechanical loading) regulate its expression.