Andrew Elia, M.D., Ph.D.

Physician Investigator (Cl)
Radiology, Mass General Research Institute
Assistant Professor of Radiation Oncology
Harvard Medical School
Assistant In Radiation Oncology
Massachusetts General Hospital
M.D.; Ph.D. Harvard Medical School 2005
brca1 protein; cancer; cdc25 phosphatases; ddr disruption; dna damage; dna damage response; dna repair; genes tumor suppressor; phosphopeptides; phosphoproteins; phosphoserine; phosphothreonine; protein kinases; replication protein a; stalled replication forks; ubiquitin-dependent signaling; ubiquitin-protein ligases In response to DNA damage from environmental or endogenous sources, cells evoke an elaborate signaling network known as the DNA damage response (DDR). This response functions to preserve genomic integrity, which is necessary for normal development and the prevention of cancer. The Elia laboratory studies pathways in the DNA damage response. Current projects focus on DDR pathways regulated by ubiquitin-dependent signaling and pathways that promote the stabilization and repair of stalled replication forks. We utilize proteomic and genetic approaches to investigate these processes. Our ultimate goal is to understand how DDR disruption influences cancer progression and can be exploited to target tumors with specific DNA repair defects.