Investigator, Assoc Prof (M) Molecular Pathology Unit, Mass General Research Institute

Associate Professor of Pathology Harvard Medical School

Janet and William Ellery James MGH Research Scholar 2020-2025 Mass General Research Institute, Massachusetts General Hospital

Affiliate Faculty Principal Faculty, Harvard Stem Cell Institute

Associate Member Institute Member, Broad Institute

cancer stem cells; diffuse intrinsic pontine glioma; glioblastoma; gliomas; sarcoma ewing; single-cell genomics; single-cell rna-seq The laboratory is focused on the biology of brain tumors, in particular diffuse high-grade gliomas in adults and children. My group studies how cellular heterogeneity and plasticity contribute to tumor cell properties. We study heterogeneity in primary human samples, establishing transcriptional and genetic profiling from single cells. We seek to identify novel vulnerabilities in brain tumors.