Tatsuo Kawai, M.D., Ph.D.
|
Clinicn Investigator, Full Prf Surgery, Mass General Research Institute |
|
Professor of Surgery Harvard Medical School |
|
Visiting Surgeon Transplant Surgery, Massachusetts General Hospital |
|
Director, Legorreta Center for Clinical Transplant Tolerance Massachusetts General Hospital |
| MD Nihon University 1981 |
| PhD Tokyo Women's Medical University 1991 |
Research Interests
Research Narrative
Our clinical and research interests are primarily focused on development of methods to induce immunological tolerance in organ transplantation. We reported, for the first time, a consistent model for induction of renal allograft tolerance in nonhuman primates through a mixed chimerism approach in 1995. This and subsequent pre-clinical reports have extended this approach to the world’s first clinical trials for induction of renal allograft tolerance in HLA mismatched kidney transplantation. This is a seminal achievement of a clinical protocol leading to the first reproducibly successful induction of renal allograft tolerance in humans and was reported in the New England Journal of Medicine in 2008 and 2013.
Most recently, we resumed clinical trial for induciton of tolerance in living donor kidney transplantation with the revised regimen, which will be extednded to deceased donor transplantation.
In the field of xenotransplantation, we collaborated extensively with eGenesis over the past five years, achieving over two years of survival for genetically edited kidney xenografts in nonhuman primates, which was published in Nature in 2023. In March 2024, we performed the world first kidney xenotransplantation from the pig with 69 genomic edits in a living patient with end stage renal disease.
| tkawai@mgh.harvard.edu |
| 6177260289 |
|
White Building 55 Fruit Street 521B Boston, MA 02114 |