Instructor in Investigation Laboratory for Tissue Engineering and Organ Fabrication, Mass General Research Institute

Instructor in Surgery Harvard Medical School

Research Staff Pediatric Surgery, Massachusetts General Hospital

PhD China Agricultural University 2011

cell biology; extracellular matrix; induced pluripotent stem cells; lung diseases; lung transplantation; organ regeneration; organoids; stem cell differentiation; stem cell therapy; tissue engineering; whole organ scaffolds We had validated the native acellular scaffold in regards to matrix integrity and structure, and cellular biocompatibility, and had generated endothelial and lung epithelial cells from human induced pluripotent stem cells for human organ regeneration on both rat and porcine lung scaffold. Our goal is to establish a whole lung regeneration model utilizing patient specific iPS cells derived cells on acellular scaffold with our ex vivo biomimetic culture system. Our model will not only provide a solid and practical foundation for lung engineering which will ultimately benefit patients suffering from lung failure, but also provide a highly clinical relevant model to study the diseases mechanism and therapy of many lung diseases.