Paul Huang, M.D., Ph.D.

Physician Investigator (Cl)
Cardiovascular Research Center, Mass General Research Institute
Professor of Medicine
Harvard Medical School
Cardiology, Massachusetts General Hospital
Principal Faculty
Harvard Stem Cell Institute
PhD 1985
atherosclerosis; beta cell function; brain ischemia; glucose tolerance; ischemic preconditioning; metabolic syndrome x; nitric oxide; nitric oxide donors; nitric oxide synthase; nitric oxide synthase type i; nitric oxide synthase type ii; nitric oxide synthase type iii; vascular dysfunction

Dr. Paul Huang's research focuses on the roles of nitric oxide (NO) in cardiovascular disease and metabolism, using techniques ranging from molecular biology, physiology, and genetically altered mouse models, to human translational studies and induced pluripotent stem (iPS) cell approaches.

His research laboratory is studying how the metabolic abnormalities seen in diabetes and obesity affect vascular function and predispose to cardiovascular disease, including stroke and heart attack. His most recent work shows the importance of eNOS phosphorylation to atherosclerosis, stroke, and insulin resistance.

Clinically, Dr. Huang leads the Cardiac Metabolic Syndrome Program in the MGH Cardiovascular Disease Prevention Center. He is PI of the translational research CAMP MGH Study (MGH Cardiology and Metabolic Patient Cohort), the first and largest cohort derived from MGH Heart Center patients with detailed phenotyping, genotyping, and physiologic characterization of glucose tolerance and vascular dysfunction.

As a member of the Harvard Stem Cell Institute, Dr. Huang is deriving iPS cells from subjects carrying genetic variants that increase risk for type 2 diabetes to test beta cell function, and from subjects with chemotherapy induced cardiomyopathy to test cardiac myocytes contractility.

Publications Clinical Profile

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