Warren Zapol, M.D.
Physician Investigator (NonCl)
Anesthesia, Critical Care and Pain Medicine, Mass General Research Institute
Reginald Jenney Distinguished Professor of Anaesthesia
Harvard Medical School
|MD University of Rochester School of Medicine and Dentistry 1966|
Research in the Zapol Lab is directed at understanding a wide range of critical illnesses that can be therapeutically treated with novel inhaled gases. Inhaled nitric oxide (NO) is a central focus of the laboratory research, both as a selective pulmonary vasodilator and a safe method for loading the body with NO donor molecules. As a selective pulmonary vasodilator, inhaled NO is used to treat pulmonary hypertension and to improve ventilation-perfusion matching of the lung. NO inhalation leads to the formation of circulating NO metabolites, which after conversion to NO, can neutralize oxygen free radicals, activate soluble guanylate cyclase (to make cGMP) and prevent the side effects of excessive scavenging of endogenous NO molecules by transfusion of stored red cells. The prevention and treatment of acute lung injury is also studied with murine models of ventilator-induced lung injury and transfusion. We also study sickle cell anemia seeking novel inhibitors of sickling. Metals in vaping gas and their toxicity with BU colleagues . With the Wellman labs we study red light phototherapy of CO poisoning.
Animal models used in the laboratory extend from mice to sheep and pigs, with a special focus on translational research to improve the care of critically ill patients.